Senior Research Associate, Cell Science

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a Senior Research Associate in Cell Science to support cell line development through hands-on cell biology, CHO cell line development, and functional assay execution. This role is lab-based and requires deep experience with CHO cell culture and mammalian expression systems.

You will work cross-functionally with Protein Engineering and Process Development teams to generate and characterize stable cell lines, support expression of antibody and multi-specific formats, and deliver high-quality data to advance pipeline programs.

This role requires full-time onsite presence in our Bothell, WA facility.

Responsibilities
CHO Cell Line Development

• Maintain mammalian cell cultures
• Generate and maintain stable CHO cell lines for antibody expression
• Perform transfection, clone selection, single-cell cloning, and productivity screening
• Support cell banking activities and maintain detailed documentation
• Perform expression vector construction, plasmid preparation, and NGS sequencing

Data Analysis & Documentation

• Analyze and interpret experimental data
• Maintain accurate electronic lab notebook records
• Present findings clearly to cross-functional teams

Cross-Functional Collaboration

• Contribute to troubleshooting, assay development, and process improvements
• Operate effectively in a fast-paced, early-stage R&D environment

Qualifications

• BS or MS in Cell Biology, Molecular Biology, Biochemistry, or related field
  • Senior Research Associate requires bachelor’s degree with 5+ years or master’s degree with 3+ years of industry experience.
• Strong background in mammalian cell biology and expression systems
• Demonstrated hands-on expertise in CHO cell culture and stable cell line development
• Ability to thrive in a fast-paced team environment and deliver complex objectives under tight deadlines
• Availability of working weekend and holiday shifts as needed

Required Technical Skills

• CHO suspension culture and clone screening
• Stable transfection methods
• Cell Biology and Molecular Biology laboratory skills
• Familiarity with antibody or multi-specific biologics preferred
• Strong experimental design and troubleshooting skills

Compensation and Benefits:
The expected base salary range for this position is $70,000 - $90,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.
 
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
 
We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
 
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.