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Role description

Founding Engineer

Astraea logoAstraeaYC X26
Founding roleAI-native
TypeFull-time
SenioritySenior
SponsorshipSponsors visas
Salary$150,000–$300,000
LocationSan Francisco, CA
Engineering

We are looking for a founding engineer who wants to build deeply technical AI systems in one of the most important and regulated industries in the world.

You will work directly with the founders to:

  • Build agentic workflows for clinical trial automation
  • Design reliable systems for document ingestion, data transformation, validation, and auditability
  • Own core product surfaces across frontend, backend, data infrastructure, and AI orchestration
  • Work closely with clinical teams to turn messy real-world workflows into production software
  • Ship quickly while maintaining the rigor required for regulated healthcare environments

You might be a fit if you:

  • Are an exceptional full-stack or backend engineer
  • Care about building reliable, production-grade AI systems and can/have integrated into legacy systems in the past
  • Move fast, take ownership, and like ambiguous technical problems
  • Are excited by using AI to automate healthcare, clinical trials, or regulated data workflows
  • Want to join at the earliest stage and help define the engineering culture

We care less about credentials and more about raw ability, taste, speed, and ownership. This is a high-agency founding role for someone who wants to build category-defining software.

Relevant archetypes

Apply on Y Combinator
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Company info

Astraea logo

Astraea

AI Operating System for Clinical Development

SeedYC X26Fresh from YCBrand new
Founded2026
Size1–10 employees
Unlock human wisdom
ThesisTermsPrivacy
Industry
Technology, Information and Internet
Funding
  • Seed · $870K · Jun 6, 2026
  • Pre-seed · Apr 23, 2026

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