Therapeutics Architect

WHY NOETIK

NOETIK is a frontier therapeutics company harnessing AI to deeply understand human biology and redefine clinical outcomes in oncology. Leveraging the largest proprietary multimodal oncology dataset of its kind, uniquely integrating deep spatial profiling with routine clinical assays, NOETIK’s foundation AI models precisely match therapeutic targets to patient subpopulations and accurately predict clinical efficacy. This AI-first approach elevates therapeutic development from probabilistic guesswork to precision science.

THE REMIT OF THE BIOLOGIST IS CHANGING

Drug discovery and development is a decision-making problem. We are generating more data and building better models, but real impact comes from knowing which questions matter and what evidence actually impacts a program’s trajectory. We need scientists who can pair model-driven outputs with sharp therapeutic judgment to figure out which therapies should exist, and for whom. 

In this role, you’ll turn those outputs into evidence-based recommendations for therapeutic programs. This means being deep in biology and therapeutic concepts, while also being genuinely engaged with frontier AI and how that is changing how we work. You’ll work alongside experienced drug discovery and development colleagues to build and test better ways of working.

THE OPPORTUNITY

You'll join a cross-functional therapeutics team responsible for surfacing promising therapeutic opportunities, pressure-testing their scientific and translational logic, and shaping how programs move through the pipeline. We're intentionally building a different kind of therapeutics group to support this work, because turning human foundation models / insights into new therapeutic concepts and real patient impact requires a fundamentally different way of working.

The people who will thrive here bring scientific depth, curiosity, and an AI-native perspective, incorporating agentic tools and machine intelligence into how they reason through problems. They ask what an AI-native platform can reveal and what those insights mean for therapeutic decisions. They want to develop their ability to distinguish an interesting hypothesis from a viable therapeutic concept and to weigh opportunities beyond their own project. This is a hands-on individual contributor role suited to scientists building their careers in drug discovery; you don’t need to have led a portfolio or taken a program from discovery to the clinic.

This is a hybrid role based in New York, with ~three days per week in the office.

Key Responsibilities:

• Evaluate biological insights and therapeutic opportunities, taking ownership of focused analyses and developing recommendations with the therapeutics team.
• Work cross-functionally to move programs forward by identifying key scientific questions, proposing decision criteria, and contributing to the next steps
• Develop platform-informed hypotheses around therapeutic targets, mechanisms, patient populations, biomarkers, and clinical strategy
• Build evidence packages that inform investment, partnering, and development decisions
• Design and improve AI-enabled scientific workflows that increase the durability and quality of therapeutic decision-making
• Compare therapeutic opportunities and contribute to team prioritization by assessing biological rationale, technical feasibility, clinical impact, and strategic fit

WHAT WE’RE LOOKING FOR

The strongest candidates are curious across disciplines and comfortable working through uncertainty. They use AI tools to explore ideas, challenge assumptions, and surface hypotheses, then bring scientific judgment to the results: checking evidence, recognizing weak or circular reasoning, and distinguishing plausible outputs from meaningful ones. They bring depth in a relevant area of biology and an interest in broadening their therapeutic judgment. They communicate their reasoning clearly, seek feedback, and adapt when the evidence changes.

Qualifications:

• PhD, MD, or equivalent experience in cancer biology, immunology, pharmacology, molecular biology, translational medicine, or a related discipline
• Hands-on research experience relevant to drug discovery or translational science, gained through doctoral or postdoctoral research, industry collaborations, or an initial industry role. You can explain how your work informed a therapeutic hypothesis, target-validation decision, or next experiment; prior program leadership is not required
• A strong foundation in disease biology and the ability to connect mechanistic evidence to therapeutic hypotheses, with an interest in building knowledge of modality selection, translational strategy, and clinical positioning
• Curiosity and a collaborative approach to working with colleagues across biology, machine learning, computational science, and strategy
• Hands-on use of modern AI tools in scientific work, with examples of how they’ve changed the way you investigate questions, evaluate evidence, or make therapeutic decisions 
• A systems-thinking mindset and the ability to explain trade-offs between scientific hypotheses or experiments
• Sound scientific judgment, clear communication, and the ability to explain evidence, uncertainty, and recommendations to colleagues across disciplines
• Bonus: experience with computational biology, data science, machine learning, or programming (Python, R, SQL), though deep biological reasoning and therapeutic judgment are more important than any particular technical stack

Life@Noetik

Great science is a team sport. We are focused on creating a culture where brilliant people from different backgrounds can solve hard problems together. At Noetik, culture isn't just about perks; it’s about building a vibrant, collaborative community where everyone has the tools and the autonomy to thrive.

How We Work

Location & Collaboration: our primary lab and office space is located in South San Francisco. We operate as a hybrid organization, utilizing Slack, Zoom, and a modern tech stack to stay seamlessly connected regardless of time zone.

Intentional Connection: we believe that high-impact work requires intentional time together. We keep the team aligned through monthly All-Hands meetings and Quarterly Co-working Weeks at our South San Francisco office. Once a year, we gather for an Annual Reset - a week-long offsite dedicated to high-level strategy, collaboration and team bonding. Past locations have included Austin, TX, Park City, UT, and Boulder, CO.

Onsite Community: For team members working onsite, we foster a collaborative environment and refuel with daily catered lunches from great local restaurants and Boba Thursday - a small but meaningful tradition where we step away from our desks to connect over a break.

How We Support You

Health & Wellbeing: we provide generous health, dental, and vision insurance, with premiums fully covered for both employees and their dependents (depending on your plan choice). Our coverage is designed to be comprehensive and accessible, featuring modern care platforms like OneMedical, Midi Health, Spring Health, and XP Health. To further support your needs, we offer HSA and FSA accounts, dependent care savings, an EAP, resources for mental health (Rula), and health care navigation and advocacy (Rightway).

Time Off & Synchronized Breaks: we offer Flexible PTO to manage your personal time, alongside nine paid holidays. We also offer synchronized breaks so that the team can fully unplug simultaneously -  two full-week company breaks (the first week of July and the last week of December), plus the Friday after Thanksgiving.

Compensation & Financial Benefits: our financial package includes a competitive base salary, stock options, and a 401(k) plan with an employer match. We provide a safety net through fully-covered disability, life and AD&D insurance, as well as generous parental leave. We also offer a suite of financial and lifestyle tools, including SoFi, Multiply Mortgage, and optional programs for pet insurance, legal services, and identity theft protection.

We believe that the highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other.  We are committed to an open, diverse and inclusive culture for all employees. Noetik is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status and any other characteristics protected under applicable federal, state and local laws.