Senior Research Associate, In Vivo Pharmacology

Why this role matters.

Our gene editing programs for neurodegenerative diseases can only advance if in vivo studies show that an editor works in a living animal. This role carries those studies from dosing through tissue collection to the molecular readout. The data you generate feeds the preclinical and IND-enabling work that decides whether a program moves forward. 

This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4–5 days per week.

What you'll own.

• Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy.
• Set up and schedule studies, and coordinate between the laboratory and the animal facility.
• Process tissues and biological samples, and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis.
• Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
• Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools.
• Present findings, study progress, and data summaries to project teams and cross-functional collaborators.
• Keep study records, sample inventories, and protocols accurate and current.

What you've done. 

• Bachelor’s degree in pharmacology, biology, neuroscience, molecular biology, or a related field with 3+ years of industry experience, or a master’s degree with 1+ year.
• Has run in vivo rodent studies hands-on, including dosing, monitoring, blood collection, tissue harvest, and necropsy.
• Has dosed rodents by intravenous, retro-orbital, or comparable routes.
• Has processed animal tissues and biological samples for molecular, biochemical, or pharmacodynamic endpoints.
• Has run molecular and biochemical assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope; flow cytometry experience preferred.
• Has managed samples and timelines across more than one study at a time.
• Has supported IND-enabling studies (preferred).

What you'll get.

The anticipated base salary range for this role is $85,000–$95,000. Actual pay depends on relevant experience, skills, education, internal equity, and other job-related factors.

Every employee is eligible for a bonus and new hire equity. We pay about 90% of medical, dental, and vision premiums and fund the full deductible on our HSA plan. You'll also get 12 weeks of parental leave at full pay, paid parking or transit, a 401(k) match, and discretionary time off.

Arbor is an equal opportunity employer. We're committed to a hiring process and a workplace free of bias and discrimination, and we welcome candidates of every background.